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Anti-hepatitis B activities of ganoderic acid from Ganoderma Lucidum

 College of Life Science, South China Normal University, Guangzhou, P.R. Chi

Ganoderic acid, from Ganoderma lucidum, at 8 µg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg•d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).

PMID: 16786250 [PubMed – indexed for MEDLINE]

Ganoderma lucidum( reishi)

  




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